"Desolation" is the rejection, perversion, violation of God's Will, His Laws, and Commandments by many of the leaders of the so-called Christian religions, who, by interpreting God's distorted Word, spread it among their followers.
"Desolation" is also the spiritual desolation of the representatives of the various "Churches," the beliefs of the pseudo-Christian world.
"Desolation" is a figurative characteristic of the moral and spiritual corruption of man by sin, wickedness due to his godlessness, rejection, the Will of God, his arrogance, pride, and soulless way of life.
"Desolation" is also a state of passivity, inactivity, spiritual, mental, moral impoverishment of man, who satisfies only his carnal needs, concerns, for whom the Laws of God, His Commandments, spiritual priorities are not significant in his life.