The "Work" of God is a symbol of the fulfillment of God's Plans, His Predestinations, His Laws.
The "Work" of God is God's creation of the visible and invisible World, of all Being, and of God's highest incarnation in His Creation - His spiritual "Image" and "Likeness" - Man.
The "work" of man's hands is a symbol of man's study of the Word of Holy Scripture, of the fulfillment and proclamation of God's Will and His Commandments, a symbol of all righteous works of man.
Negative Meaning.
"The "work" of man's hands is a symbol of his sinful deeds, the creation of pernicious ideologies and false doctrines, a symbol of the consequences of his rejections and violations of God's Commandments.